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学者姓名：盛望
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| GB/T 7714 | Wang, Li , Li, Jintao , Zhang, Na et al. Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020) [J]. | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2021 , 558 : 239-239 . |
| MLA | Wang, Li et al. "Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020)" . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 558 (2021) : 239-239 . |
| APA | Wang, Li , Li, Jintao , Zhang, Na , Zhang, Xiaofei , Xia, Yang , Chai, Binbin et al. Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020) . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2021 , 558 , 239-239 . |
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摘要 ：
Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC therapy. However, the efficacy of combination therapy can be restricted due to increasing therapeutic resistance to various treatments. Herein, we constructed a nanodiamond (ND)-based nanoplatform for augmented mild-temperature photothermal/chemo combination therapy against TNBC, weakening the therapeutic resistance via autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects via suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance via autophagy inhibition, leading to augmented combination therapy that is efficient both in vitro and in vivo. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy via an autophagy regulation strategy against TNBC.
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| GB/T 7714 | Cui, Xinyue , Liang, Zhaoyuan , Lu, Jianqing et al. A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy [J]. | NANOSCALE , 2021 , 13 (31) : 13375-13389 . |
| MLA | Cui, Xinyue et al. "A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy" . | NANOSCALE 13 . 31 (2021) : 13375-13389 . |
| APA | Cui, Xinyue , Liang, Zhaoyuan , Lu, Jianqing , Wang, Xuan , Jia, Fan , Hu, Qin et al. A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy . | NANOSCALE , 2021 , 13 (31) , 13375-13389 . |
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摘要 ：
Uniting combinational strategies has been confirmed to be a robust choice for high-performance cancer treatment due to their abilities to overcome tumor heterogeneity and complexity. However, the development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. In this study, we integrated multicomponent hyaluronic acid (HA), protamine (PS), nanodiamonds (NDs), curcumin (Cur), and IR780 into a single nanoplatform (denoted as HPNDIC) based on the combination of hydrophobic and electrostatic noncovalent interactions for dual-modal fluorescence/photoacoustic imaging guided ternary collaborative Cur/photothermal/photodynamic combination therapy of triple-negative breast cancer (TNBC). A two-step coordination assembly strategy was utilized to realize this purpose. In the first step, PS was utilized to modify the NDs clusters to form positively charged PS@NDs (PND) and the simultaneous encapsulation of the natural small-molecule drug Cur and the photosensitive small-molecule IR780 (PNDIC). Second, HA was adsorbed onto the outer surface of the PNDIC through charge complexation for endowing a tumor-targeting ability (HPNDIC). The resulting HPNDIC had a uniform size, high drug-loading ability, and excellent colloidal stability. It was found that under the near-infrared irradiation condition, IR780 could be triggered to exhibit both PTT/PDT dual-pattern therapy effects, leading to an enhanced therapy efficiency of Cur both in vitro and in vivo with good biocompatibility. Due to the intrinsic imaging property of IR780, the biodistribution and accumulation behavior of HPNDIC in vivo could be monitored by dual-modal fluorescence/photoacoustic imaging. Taken together, our current work demonstrated the assembly of a NDs-based multicomponent theranostic platform for dual-modal fluorescence/photoacoustic imaging guided triple-collaborative Cur/photothermal/photodynamic against TNBC.
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| GB/T 7714 | Cui Xinyue , Deng Xiongwei , Liang Zhaoyuan et al. Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy. [J]. | Biomaterials science , 2021 , 9 (10) : 3838-3850 . |
| MLA | Cui Xinyue et al. "Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy." . | Biomaterials science 9 . 10 (2021) : 3838-3850 . |
| APA | Cui Xinyue , Deng Xiongwei , Liang Zhaoyuan , Lu Jianqing , Shao Leihou , Wang Xuan et al. Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy. . | Biomaterials science , 2021 , 9 (10) , 3838-3850 . |
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摘要 ：
In the present study, we evaluated adjuvant potential of Poria cocos polysaccharide (PCP) on the Th1-type immune responses of C57/BL6 mice against ovalbumin (OVA). We first determined the effect of PCP on maturation of murine bone marrow derived dendritic cells (BMDCs), PCP significantly upregulated surface expression of MHCII, CD40, CD80, CD86 and enhanced production of IL-6 and IL-12p40. In addition, PCP affected receptor-mediated endocytosis, but not pinocytosis in BMDCs. Furthermore, OVA + PCP immunization induced specific cytotoxic CD8+ T cell killing of OVA (257-264) peptide pulsed cell. When mice were immunized subcutaneously in a week interval with OVA + PCP. Serum were collected for measuring OVA-specific antibody and splenocytes were harvested for analyzing CD69, IFN-γ ELISpot and cytokines production. The result indicated that OVA-specific IgG, IgG2a and IgG1 antibody levels in serum were significantly elevated by PCP compared with control. PCP increased OVA-specific IFN-γ-secreting CD8+, CD4+ T cells, promoted CD8+ T cell proliferation and up-regulated Th-1 type (IFN-γ, IL-2) cytokine production. In conclusion, data suggest that PCP enhanced cellular immune response and possess potential as a vaccine adjuvant for Th1 immune response.
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| GB/T 7714 | Dong Xiaoxiao , Li Boye , Yu Boyang et al. Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice. [J]. | PloS one , 2021 , 16 (1) : e0245207 . |
| MLA | Dong Xiaoxiao et al. "Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice." . | PloS one 16 . 1 (2021) : e0245207 . |
| APA | Dong Xiaoxiao , Li Boye , Yu Boyang , Chen Tian , Hu Qin , Peng Bo et al. Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice. . | PloS one , 2021 , 16 (1) , e0245207 . |
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摘要 ：
Traditional brazing quality inspection methods find it difficult to detect brazing layer defects on heteromorphic workpieces. Thus, a non-destructive testing technology based on a thermal probe is developed in this work. Scanning thermal resistance testing and analysis are carried out for two types of workpiece samples with different structures, and an evaluation calculation method is proposed to effectively characterize the brazing effect of the workpiece. By comparison with standard workpieces, qualified brazing layer products can be selected. In addition, the feasibility of this method is verified by ANSYS thermal simulations. In comparison with the x ray, it also has shown the superiority of this method. Experimental results show that this method can effectively evaluate the brazing layer quality of workpieces with heteromorphic and complex structures, and the reliability of the workpiece is further improved. Published under an exclusive license by AIP Publishing.
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| GB/T 7714 | Hu, Chaoxu , Feng, Shiwei , Zhang, Yamin et al. A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe [J]. | REVIEW OF SCIENTIFIC INSTRUMENTS , 2021 , 92 (8) . |
| MLA | Hu, Chaoxu et al. "A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe" . | REVIEW OF SCIENTIFIC INSTRUMENTS 92 . 8 (2021) . |
| APA | Hu, Chaoxu , Feng, Shiwei , Zhang, Yamin , He, Xin , Bai, Kun , Wang, Sheng et al. A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe . | REVIEW OF SCIENTIFIC INSTRUMENTS , 2021 , 92 (8) . |
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摘要 ：
Cancer vaccines targeting tumor specific neoantigens derived from nonsynonymous mutations of tumor cells have emerged as an effective approach to induce antitumor T cells responses for personalized cancer immunotherapy. Despite the enormous potential of synthetic peptides as a common modality for neoantigen vaccines, their practical efficacy was limited due to their relatively low immunogenicity. Herein, we modify neoantigen peptide (Adpgk) derived from MC-38 colon carcinoma by supplementing ten consecutive positively-charged lysines (10 K-Adpgk) to obtain cationic polypeptide. And then we made them self-assemble with toll-like receptor 9 (TLR-9) agonist CpG oligodeoxynucleotides (CpG ODN) adjuvant directly forming antigen/adjuvant integrated nanocomplexes (PCNPs) through electrostatic interaction for potent tumor immunotherapy. The optimal formed PCNPs were around 175 nm with uniform size distribution and could maintain stability in physiological saline solution. CpG ODN and 10 K-Adpgk in the formed PCNPs could be effectively uptake by dendritic cells (DCs) and stimulate the maturation of DCs as well as improving the efficiency of antigen crosspresentation efficiency in vitro. Furthermore, the PCNPs vaccine could markedly improve neoantigen and adjuvant co-delivery efficiency to lymphoid organs and activate cytotoxic T cells. In addition, vaccination with PCNPs could not only offer prophylactic to protect mice from challenged MC-38 colorectal tumors, but also achieve a better anti-tumor effect in an established colorectal tumor model, and significantly prolong the survival rate of tumor-bearing mice. Therefore, this work provided a versatile but effective method for neoantigen peptide and CpG ODN co-assembly vaccine platform for efficient colorectal cancer immunotherapy.
关键词 ：
CpG ODN CpG ODN Immunotherapy Immunotherapy Nanovaccine Nanovaccine Neoantigen Neoantigen Peptide Peptide
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| GB/T 7714 | Liang, Zhaoyuan , Cui, Xinyue , Yang, Liqun et al. Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2021 , 608 . |
| MLA | Liang, Zhaoyuan et al. "Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 608 (2021) . |
| APA | Liang, Zhaoyuan , Cui, Xinyue , Yang, Liqun , Hu, Qin , Li, Danyang , Zhang, Xiaofei et al. Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2021 , 608 . |
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摘要 ：
Digital sensor arrays based on ring oscillators are used to monitor the temperature of Field Programmable Gate Array (FPGA) chips, but traditional sensor structures using binary frequency counters consume excessive hardware logic resources. This paper proposed a compact temperature sensor array that used low-decoding-complexity linear feedback shift registers (LFSR) as a frequency counter to efficiently count the ring oscillator frequency. We implemented an experimental system on a Spartan-6 FPGA, and the logic resource consumption of the entire system was 927 Look-Up-Tables (LUTs) with an overhead of only 10%. The single sampling time was approximately 40 μs. The proposed temperature sensor array has good temperature sensing capabilities, and the measured error is ±0.9°C(3σ). © 2021 Elsevier Ltd
关键词 ：
Computer circuits Computer circuits Field programmable gate arrays (FPGA) Field programmable gate arrays (FPGA) Logic gates Logic gates Shift registers Shift registers Table lookup Table lookup Temperature sensors Temperature sensors
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| GB/T 7714 | Wang, Sheng , Feng, Shiwei , Xiao, Yuxuan et al. Build-in compact and efficient temperature sensor array on field programmable gate array [J]. | Microelectronics Journal , 2021 , 111 . |
| MLA | Wang, Sheng et al. "Build-in compact and efficient temperature sensor array on field programmable gate array" . | Microelectronics Journal 111 (2021) . |
| APA | Wang, Sheng , Feng, Shiwei , Xiao, Yuxuan , Hu, Chaoxu , Pan, Shijie . Build-in compact and efficient temperature sensor array on field programmable gate array . | Microelectronics Journal , 2021 , 111 . |
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摘要 ：
在微流控技术加工的网络图案化芯片上培养大鼠原代海马神经元细胞,从而探究体外神经元网络的生物学功能.目的:在培养过程中,我们设计的网络化图案来限定海马神经元的体外的粘附,生长及形成具有功能性的神经网络,在此基础上研究网络图案化的微流控芯片3D微通道中单个海马神经元的生物学功能.方法:利用膜片钳技术探测微通道中不同区域单个海马神经元的膜突触后电位,从而验证单个海马神经元可以与其他神经元细胞形成有效的突触连接,从而保证单一神经元具有基本的生物学活性;继而运用Image J软件进行神经突起结构的定量分析,并通过软件分析输出突起长度数据,并进行SPSS统计分析得到3D微通道培养单个海马神经元细胞平均突起长度.结果:3D微通道不同区域随机探测,均可探测到单个海马神经元的膜突触后电位;同时神经突起结构的定量分析反映了实际的神经元结构分布趋势,且统计分析结果显示,单个海马神经元平均突起长度为68.3μm.结论:基于微流控芯片技术的3D微通道可以使神经元细胞按照图案化的路径生长从而形成特定神经网络,而且其中培养的海马神经元均具有成熟生物学功能,可以形成有效的突触连接,也为单个海马神经元功能的探究提供了思路.
关键词 ：
海马神经元 海马神经元 微流控芯片 微流控芯片 神经元突起 神经元突起 3D微通道 3D微通道 膜突触后电位 膜突触后电位
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| GB/T 7714 | 孔宪敏 , 田姗姗 , 陈涛 et al. 基于微流控芯片的3D微通道中单个海马神经元功能的探究 [J]. | 科技通报 , 2020 , 36 (4) : 40-44,71 . |
| MLA | 孔宪敏 et al. "基于微流控芯片的3D微通道中单个海马神经元功能的探究" . | 科技通报 36 . 4 (2020) : 40-44,71 . |
| APA | 孔宪敏 , 田姗姗 , 陈涛 , 盛望 . 基于微流控芯片的3D微通道中单个海马神经元功能的探究 . | 科技通报 , 2020 , 36 (4) , 40-44,71 . |
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摘要 ：
目的:在纳米水平直观验证表皮生长因子受体(EGFR)和肝细胞生长因子受体(c-Met)是否可以结合形成异源二聚体。方法:采用链霉亲和素-生物素技术,利用2种不同大小的纳米金颗粒(10和30 nm)分别结合核酸适配体对EGFR和c-Met进行共标记和共定位;采用环境扫描电镜对2种膜蛋白进行纳米尺度下的超高分辨成像观察,并开展统计分析。结果:三阴性乳腺癌细胞膜表面EGFR单体、二聚体、多聚体的占比分别为48.60%、29.83%、21.57%,cMet单体、二聚体、多聚体的占比分别为38.24%、27.66%、34.10%;EGFR、c-Met可以聚合形成异源二聚体和多聚体,分别占二聚体和多聚体总...
关键词 ：
三阴性乳腺癌 三阴性乳腺癌 共定位 共定位 扫描电镜 扫描电镜 肝细胞生长因子受体(c-Met) 肝细胞生长因子受体(c-Met) 表皮生长因子受体(EGFR) 表皮生长因子受体(EGFR)
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| GB/T 7714 | 柴彬彬 , 王丽 , 李劲涛 et al. 三阴性乳腺癌细胞膜表面EGFR和c-Met的单分子水平共定位研究 [J]. | 生物技术通讯 , 2020 , 31 (01) : 66-70 . |
| MLA | 柴彬彬 et al. "三阴性乳腺癌细胞膜表面EGFR和c-Met的单分子水平共定位研究" . | 生物技术通讯 31 . 01 (2020) : 66-70 . |
| APA | 柴彬彬 , 王丽 , 李劲涛 , 张晓菲 , 夏阳 , 吉元 et al. 三阴性乳腺癌细胞膜表面EGFR和c-Met的单分子水平共定位研究 . | 生物技术通讯 , 2020 , 31 (01) , 66-70 . |
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摘要 ：
基于氧化石墨烯的茯苓多糖纳米佐剂及佐剂/抗原共递送疫苗的制备与应用，属于药物领域。该发明包括以纳米氧化石墨烯材料作为载体，与负载在该载体上的茯苓多糖形成的茯苓多糖纳米佐剂，及由该佐剂与抗原形成的佐剂/抗原共递送疫苗。茯苓多糖纳米佐剂能促进树突状细胞成熟，增强淋巴细胞功能，并利于药物缓释，有效地延长药效，防止免疫耐受，极大增强了免疫效果和反应时间。佐剂/抗原共递送疫苗增强了茯苓多糖和抗原的生物利用率，使抗原和佐剂可被同一细胞摄取，大大增强疫苗靶向性，该疫苗不仅可诱导体液免疫，同时还能诱导较强的细胞免疫。本发明作为一种新型佐剂及疫苗，可预期用于人类疾病的预防和治疗。
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| GB/T 7714 | 胡秦 , 于渤洋 , 窦相南 et al. 基于氧化石墨烯的茯苓多糖纳米佐剂及佐剂/抗原共递送疫苗的制备与应用 : CN202011159718.7[P]. | 2020-10-26 . |
| MLA | 胡秦 et al. "基于氧化石墨烯的茯苓多糖纳米佐剂及佐剂/抗原共递送疫苗的制备与应用" : CN202011159718.7. | 2020-10-26 . |
| APA | 胡秦 , 于渤洋 , 窦相南 , 董晓筱 , 盛望 . 基于氧化石墨烯的茯苓多糖纳米佐剂及佐剂/抗原共递送疫苗的制备与应用 : CN202011159718.7. | 2020-10-26 . |
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