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学者姓名：刘有军
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摘要 ：
Background: The underuse of invasive fraction flow reserve (FFR) in clinical practice has motivated research towards its non-invasive prediction. The early attempts relied on solving the incompressible three-dimensional Navier-Stokes equations in segmented coronary arteries. However, transient boundary condition has a high resource intensity in terms of computational time. Herein, a method for calculating FFR based on steady-state geometric multiscale (FFRSS) is proposed.Methods: A total of 154 moderately stenotic vessels (40-80% diameter stenosis) from 136 patients with stable angina were included in this study to validate the clinical diagnostic performance of FFRSS. The method was based on the coronary artery model segmented from the patient's coronary CTA image. The average pressure was used as the boundary condition for the inlet, and the microcirculation resistance calculated by the coronary flow was used as the boundary condition for the outlet to calculate the patient-specific coronary hyperemia. Then, the flow velocity and pressure distribution and the FFRss of each coronary artery branch were calculated to evaluate the degree of myocardial ischemia caused by coronary stenosis. Also, the FFRSS and FFRCT of all patients were calculated, and the clinically measured FFR was used as the "gold standard" to verify the diagnostic performance of FFRSS and to compare the correlation between FFRSS and FFRCT.Results: According to the FFRSS calculation results of all patients, FFRSS and FFR have a good correlation (r = 0.68, p < 0.001). Similarly, the correlation of FFRSS and FFRCT demonstrated an r of 0.75 (95%CI: 0.67-0.72) (p < 0.001). On receiver-operating characteristic analysis, the optimal FFRSS cut point for FFR <= 0.80 was 0.80 (AUC:0.85 [95% confidence interval: 0.79 to 0.90]; overall accuracy:88.3%). The overall sensitivity, specificity, PPV, and NPV for FFRSS <= 0.80 versus FFR <= 0.80 was 68.18% (95% CI: 52.4-81.4), 93.64% (95% CI: 87.3-97.4), 82.9%, and 91.1%, respectively.Conclusion: FFRSS is a reliable diagnostic index for myocardial ischemia. This method was similar to the closed-loop geometric multiscale calculation of FFR accuracy but improved the calculation efficiency. It also improved the clinical applicability of the non-invasive computational FFR model, helped the clinicians diagnose myocardial ischemia, and guided percutaneous coronary intervention.
关键词 ：
non-invasive diagnosis of myocardial ischemia non-invasive diagnosis of myocardial ischemia geometric multiscale geometric multiscale coronary heart disease coronary heart disease fast calculation of FFR fast calculation of FFR fractional flow reserve fractional flow reserve
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| GB/T 7714 | Liu, Jincheng , Wang, Xue , Li, Bao et al. Non-Invasive Quantification of Fraction Flow Reserve Based on Steady-State Geometric Multiscale Models [J]. | FRONTIERS IN PHYSIOLOGY , 2022 , 13 . |
| MLA | Liu, Jincheng et al. "Non-Invasive Quantification of Fraction Flow Reserve Based on Steady-State Geometric Multiscale Models" . | FRONTIERS IN PHYSIOLOGY 13 (2022) . |
| APA | Liu, Jincheng , Wang, Xue , Li, Bao , Huang, Suqin , Sun, Hao , Zhang, Liyuan et al. Non-Invasive Quantification of Fraction Flow Reserve Based on Steady-State Geometric Multiscale Models . | FRONTIERS IN PHYSIOLOGY , 2022 , 13 . |
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摘要 ：
Sigmoid sinus wall dehiscence (SSWD) is a common pathophysiology of patients with pulsatile tinnitus (PT). However, the pathological mechanism of SSWD is unclear. This study aimed to investigate the relationship between the position of the SSWD and blood flow pattern of the transverse sinus and sigmoid sinus (TS-SS) junction. The impact of the blood flow was hypothesized to be the pathological mechanism of SSWD. Twenty patients and two healthy volunteers were analyzed retrospectively, and transient computer fluid dynamics was used to verify this hypothesis. A 4D flow magnetic resonance imaging experiment was performed to validate the numerical simulation. The position of high-velocity blood flow impacting the vessel wall (17/20) was consistent with SSWD. In healthy volunteers, the temporal bone was thin where the blood flow impacted the blood vessel wall. The average wall shear stress (20/20) and pressure (18/20) of the SSWD area (peak) were higher than those of sigmoid sinus wall anomalies (the contact area between the vessel wall and the temporal bone at the TS-SS junction). The average wall pressure percentage differences of 16/20, 11/20, and 4/20 patients were more than 5%, 10%, and 20%, respectively. The average wall shear stress percentage differences of 20/20, 18/20, and 16/ 20 patients were more than 5%, 10%, and 20%, respectively. In brief, the blood flow of the TS-SS junction impacted the vessel wall and increased wall pressure, which might be an important pathological mechanism of SSWD. This study could serve as a basis for the diagnosis and SSWD resurfacing surgery of patients with PT induced by SSWD.
关键词 ：
Computational fluid dynamics Computational fluid dynamics Transverse sinus and sigmoid sinus junction Transverse sinus and sigmoid sinus junction Pulsatile tinnitus Pulsatile tinnitus 4D flow MRI 4D flow MRI Sigmoid sinus wall dehiscence Sigmoid sinus wall dehiscence
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| GB/T 7714 | Mu, Zhenxia , Li, Xiaoshuai , Zhao, Dawei et al. Hemodynamics study on the relationship between the sigmoid sinus wall dehiscence and the blood flow pattern of the transverse sinus and sigmoid sinus junction [J]. | JOURNAL OF BIOMECHANICS , 2022 , 135 . |
| MLA | Mu, Zhenxia et al. "Hemodynamics study on the relationship between the sigmoid sinus wall dehiscence and the blood flow pattern of the transverse sinus and sigmoid sinus junction" . | JOURNAL OF BIOMECHANICS 135 (2022) . |
| APA | Mu, Zhenxia , Li, Xiaoshuai , Zhao, Dawei , Qiu, Xiaoyu , Dai, Chihang , Meng, Xuxu et al. Hemodynamics study on the relationship between the sigmoid sinus wall dehiscence and the blood flow pattern of the transverse sinus and sigmoid sinus junction . | JOURNAL OF BIOMECHANICS , 2022 , 135 . |
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摘要 ：
Objective: After coronary artery bypass grafting (CABG) surgery, the main causes of poor instant patency of left internal mammary arteries (LIMAs) are competitive flow and anastomotic stenosis, but how to determine the cause of LIMA non-patency without interfering with the native coronary artery is still a difficult problem to be solved urgently.Methods: In this study, a 0D-3D coupled multiscaled CABG model of anastomotic stenosis and competitive flow was constructed. After calculation, the flow waveform of the LIMA was extracted, and the waveform shape, common clinical parameters (average flow, PI, and DF), and graft flow FFT ratio results (F0/H1 and F0/H2) were analyzed.Results: For LIMA, these three common clinical parameters did not differ significantly between the anastomotic stenosis group and competitive flow group. However, the waveform shape and FFT ratio (especially F0/H2) of the competitive flow group were significantly different from those of the anastomotic stenosis group. When the cause was competitive flow, there was systolic backflow, and F0/H2 was too high (>14.89). When the cause was anastomotic stenosis, the waveform maintained a bimodal state and F0/H2 was in a normal state (about 1.17).Conclusion: When poor instant patency of the LIMA is found after CABG, the causes can be determined by graft flow waveform shape and F0/H2.
关键词 ：
graft patency graft patency multiscaled model multiscaled model lumped parameter model lumped parameter model computational fluid dynamics computational fluid dynamics coronary artery bypass grafting coronary artery bypass grafting
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| GB/T 7714 | Mao, Boyan , Feng, Yue , Duan, Mengyao et al. A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement [J]. | FRONTIERS IN PHYSIOLOGY , 2022 , 13 . |
| MLA | Mao, Boyan et al. "A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement" . | FRONTIERS IN PHYSIOLOGY 13 (2022) . |
| APA | Mao, Boyan , Feng, Yue , Duan, Mengyao , Dong, Yihang , Li, Gaoyang , Li, Bao et al. A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement . | FRONTIERS IN PHYSIOLOGY , 2022 , 13 . |
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摘要 ：
目的体外反搏作为一种无创的辅助循环医疗装备,其治疗过程中的血流动力学效应对于缺血性血管疾病的康复治疗具有显著的意义。然而,不同反搏治疗模式引起的血流重分布状况尚不清楚。目前临床针对不同适应症都采用相同的反搏模式,缺乏区别性的反搏治疗策略。方法建立血液循环系统集中参数模型。针对体外反搏最主要的4种适应症:冠心病、脑卒中、糖尿病肾病以及糖足,将模型在心、脑、肾以及下肢处进行细化。在模型中施加不同反搏治疗模式,包括压力幅值、
关键词 ：
区别性 区别性 治疗策略 治疗策略 数值模拟研究 数值模拟研究 体外反搏 体外反搏
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| GB/T 7714 | 李鲍 , 刘金城 , 许可 et al. 不同适应症的体外反搏区别性治疗策略数值模拟研究 [J]. | 医用生物力学 , 2021 , 36 (S1) : 255 . |
| MLA | 李鲍 et al. "不同适应症的体外反搏区别性治疗策略数值模拟研究" . | 医用生物力学 36 . S1 (2021) : 255 . |
| APA | 李鲍 , 刘金城 , 许可 , 刘有军 . 不同适应症的体外反搏区别性治疗策略数值模拟研究 . | 医用生物力学 , 2021 , 36 (S1) , 255 . |
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摘要 ：
高等教育在课程建设过程中必须从育人的本质要求出发,从国家意识形态战略高度出发,提炼出落实课程思政的思政元素.而饮食文化是中国传统文化不可或缺的内容,饮食文化教学须结合理工科院校的特点和专业本身的培养目标,确定思政教育视域下饮食文化的教育理念,既要务实,也要务虚,真正提高学生的文化素养,为其树立科学的饮食观打下坚实的基础.
关键词 ：
思政教育 思政教育 饮食文化 饮食文化 教学理念 教学理念
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| GB/T 7714 | 南群 , 方亚平 , 郑大威 et al. 思政教育视域下饮食文化教学理念的转变 [J]. | 科教文汇 , 2021 , (3) : 63-65 . |
| MLA | 南群 et al. "思政教育视域下饮食文化教学理念的转变" . | 科教文汇 3 (2021) : 63-65 . |
| APA | 南群 , 方亚平 , 郑大威 , 张淑芬 , 刘有军 . 思政教育视域下饮食文化教学理念的转变 . | 科教文汇 , 2021 , (3) , 63-65 . |
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摘要 ：
目的血管病变特征直接影响狭窄处血流动力学状态,而冠脉狭窄引发的血流动力学异常是造成心肌缺血的最主要因素之一。目前,大多数研究在建模时未将血管弹性和冠状动脉粥样硬化斑块纳入考虑,而理论上血管具有弹性并且存在不同类型的斑块。因此,考虑血管弹性和斑块性质(斑块类型和重构指数)等病变特征对探究心肌缺血的影响具有意义。方法建立狭窄程度为70%的冠脉左前降支理想直管模型,采用双向流固耦合仿真计算方法分析模拟血流动力学过程,
关键词 ：
病变特征 病变特征 心肌缺血 心肌缺血 重构指数 重构指数
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| GB/T 7714 | 席晓璐 , 刘有军 . 血管病变特征对心肌缺血的影响 [J]. | 医用生物力学 , 2021 , 36 (S1) : 257 . |
| MLA | 席晓璐 et al. "血管病变特征对心肌缺血的影响" . | 医用生物力学 36 . S1 (2021) : 257 . |
| APA | 席晓璐 , 刘有军 . 血管病变特征对心肌缺血的影响 . | 医用生物力学 , 2021 , 36 (S1) , 257 . |
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摘要 ：
目的对无创计算中冠脉的3种生理状态:理想状态、静息状态、充血状态进行了理论探究。并且构建了闭环几何多尺度模型,在静息状态下无创计算瞬时无波幅比(IFR),在充血状态下计算血流储备分数(FFR)。方法闭环模型由三部分组成:心脏模块、冠脉模块、体循环模块。心脏、体循环、冠脉微循环结构简化为集总参数模型,冠脉为三维模型。分别获取不同生理状态下的流量作为个性化边界条件。通过建立冠脉理想直管模型(40%～70%)狭窄模型,对闭环模型计算FFR、
关键词 ：
多尺度模型 多尺度模型
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| GB/T 7714 | 刘金城 , 李鲍 , 刘有军 . 闭环几何多尺度模型应用于冠脉无创计算:血流储备分数和瞬时无波幅比 [J]. | 医用生物力学 , 2021 , 36 (S1) : 255 . |
| MLA | 刘金城 et al. "闭环几何多尺度模型应用于冠脉无创计算:血流储备分数和瞬时无波幅比" . | 医用生物力学 36 . S1 (2021) : 255 . |
| APA | 刘金城 , 李鲍 , 刘有军 . 闭环几何多尺度模型应用于冠脉无创计算:血流储备分数和瞬时无波幅比 . | 医用生物力学 , 2021 , 36 (S1) , 255 . |
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摘要 ：
目的探讨血流搏动对搏动性耳鸣患者的影响。方法纳入9例不同血流搏动量的搏动性耳鸣患者(对照组;血流搏动量分别增加20%、40%、60%、80%;血流搏动量分别下降20%、40%、60%、80%)。采用瞬态多物理耦合方法研究血流搏动对PT患者生物力学和声学的影响。计算乙状窦骨壁缺失区域的血流形态、压力分布、血管位移及鼓室声压水平,探讨不同血流搏动下的生物力学和声学变化。结果血流直接撞击了骨壁缺失区域的血管壁。随着血流搏动量的增大,冲击血流速度增大,
关键词 ：
搏动性耳鸣 搏动性耳鸣 多物理耦合 多物理耦合
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| GB/T 7714 | 穆振霞 , 孙宇锋 , 黄素琴 et al. 血流搏动对搏动性耳鸣患者影响的多物理耦合研究 [J]. | 医用生物力学 , 2021 , 36 (S1) : 241 . |
| MLA | 穆振霞 et al. "血流搏动对搏动性耳鸣患者影响的多物理耦合研究" . | 医用生物力学 36 . S1 (2021) : 241 . |
| APA | 穆振霞 , 孙宇锋 , 黄素琴 , 刘莉 , 薛清心 , 赵鹏飞 et al. 血流搏动对搏动性耳鸣患者影响的多物理耦合研究 . | 医用生物力学 , 2021 , 36 (S1) , 241 . |
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摘要 ：
冠状动脉血流储备分数(FFR)是反映冠状动脉病变严重程度诊断心肌功能性缺血的"金标准"。冠状动脉狭窄阻力是实现FFR数值计算的决定性因素。目前,已经有人提出基于流体力学和能量守恒来确定冠状动脉狭窄阻力的方法。随着人工智能的发展,本文开发了一种多输入反向传播神经网络(BPNN),以替代计算流体动力学过程,从而根据几何参数和血流量快速准确地预测冠状动脉狭窄阻力。本研究首先通过分析血管模型几何因素确定神经网络输入的几何参数;
关键词 ：
深度学习 深度学习 几何参数 几何参数 冠状动脉狭窄 冠状动脉狭窄 神经网络 神经网络
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| GB/T 7714 | 孙昊 , 刘有军 . 基于深度学习预测冠状动脉狭窄阻力 [J]. | 医用生物力学 , 2021 , 36 (S1) : 45 . |
| MLA | 孙昊 et al. "基于深度学习预测冠状动脉狭窄阻力" . | 医用生物力学 36 . S1 (2021) : 45 . |
| APA | 孙昊 , 刘有军 . 基于深度学习预测冠状动脉狭窄阻力 . | 医用生物力学 , 2021 , 36 (S1) , 45 . |
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摘要 ：
目的血流储备分数(FFR)是临床诊断功能性冠脉狭窄的"金标准"。现有的基于冠脉CT血管造影(CTA)和计算流体力学的几何多尺度算法实现了FFR的无创数值计算(FFRCT),但是模型复杂、仿真时间长。为了缩短计算时间,提出一种降维心血管模型快速无创数值计算FFR(FFR0D)。方法纳入73例接受了临床有创FFR的患者。根据冠脉CTA构建结构个性化的集中参数模型;基于异速标度率量化微循环阻力,通过模拟退火法优化模型参数,实现参数个性化;
关键词 ：
数值计算 数值计算 心血管模型 心血管模型
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| GB/T 7714 | 冯懿俐 , 刘有军 . 基于降维心血管模型的血流储备分数无创数值计算 [J]. | 医用生物力学 , 2021 , 36 (S1) : 253 . |
| MLA | 冯懿俐 et al. "基于降维心血管模型的血流储备分数无创数值计算" . | 医用生物力学 36 . S1 (2021) : 253 . |
| APA | 冯懿俐 , 刘有军 . 基于降维心血管模型的血流储备分数无创数值计算 . | 医用生物力学 , 2021 , 36 (S1) , 253 . |
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