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学者姓名：陈涛
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摘要 ：
This paper presents chip implementation of the integrated neural recording and stimulation system with stimulation-induced artifact suppression. The implemented chip consists of low-power neural recording circuits, stimulation circuits, and action potential detection circuits. These circuits constitute a closed-loop simultaneous neural recording and stimulation system for biomedical devices, and a proposed artifact suppression technique is used in the system. Moreover, this paper also presents the measurement and experiment results of the implemented 4-to-4 channel neural recording and stimulation chip with 0.18 mu m CMOS technology. The function and efficacy of simultaneous neural recording and stimulation is validated in both in vivo and animal experiments.
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| GB/T 7714 | Liu, Xu , Li, Juzhe , Chen, Tao et al. A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices [J]. | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
| MLA | Liu, Xu et al. "A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices" . | JOURNAL OF HEALTHCARE ENGINEERING 2021 (2021) . |
| APA | Liu, Xu , Li, Juzhe , Chen, Tao , Wang, Wensi , Je, Minkyu . A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices . | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
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摘要 ：
A novel carbon nanotubes/porous-network carbon micron tubes/silk fibroin (CPS) composite film neural electrode was presented and characterized. This electrode was fabricated through assembling dispersed carbon nanotubes (CNTs) by phytic acid onto the porous silk fibroin film. Afterward, the silk fibroin around the CNTs was carbonized by laser irradiation, producing porous-network carbon microtubes with good conductivity and biological compatibility. The structure of the CPS composite film was characterized by scanning electron microscopy and Raman spectroscopy. Cyclic voltammetry, electrochemical impedance spectroscopy, and safe charge injection limit (Q(inj)) of the CPS electrode were also measured by the three-electrode system, and the results exhibited outstanding electrochemical properties with the achieved Q(inj) of 5.7 mC/cm(2). This work provides a promising approach for the preparation of a long-term implanted neural electrode with high charge injection ability and good biocompatibility.
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| GB/T 7714 | Shen, Xuefei , Zhao, Yu , Li, Qian et al. Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode [J]. | AIP ADVANCES , 2020 , 10 (4) . |
| MLA | Shen, Xuefei et al. "Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode" . | AIP ADVANCES 10 . 4 (2020) . |
| APA | Shen, Xuefei , Zhao, Yu , Li, Qian , Chen, Tao . Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode . | AIP ADVANCES , 2020 , 10 (4) . |
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摘要 ：
Purpose: The study aims to lay a foundational probe for the thorough application microfluidic chips in brain function research with microfluidic chips. Neuron slide culture is a common culture method in vitro, and the microfluidic chip with the artificial network pattern not only can realize neuron cells 3 D culture in vitro, but also limit the extension space of neurite outgrow. Materials and Methods: In order to analyze the differences of hippocampal cells neurite growth length between the 3 D chips and the common 2 D culture, the experiments utilized statistical analysis method analyzing the length of the hippocampus neuron neurite of 3 days, 5 days and 7 days, respectively, with the common glass slide 2 D culture method and the microfluidic chip 3 D culture in vitro. Results: The results showed that there was no significant difference in the neurite length after 3 days. However, there was a significant difference after 5 days and 7 days. It can be seen that the microfluidic chip with artificial network pattern has limitations to the growth of neurite after 5 days. Conclusions: We concluded that the growth state of hippocampal cells in the restricted 3 D space is different from that of conventional 2 D culture.It showed that the artificial network pattern design has limited the growth space of the dendrites but also affected its growth.
关键词 ：
artificial network pattern artificial network pattern hippocampal cells hippocampal cells Microfluidic chip Microfluidic chip the length of neurite the length of neurite
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| GB/T 7714 | Kong, Xianmin , Chen, Tao , Huang, Yinghui . Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips [J]. | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2020 , 131 (1) : 40-43 . |
| MLA | Kong, Xianmin et al. "Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips" . | INTERNATIONAL JOURNAL OF NEUROSCIENCE 131 . 1 (2020) : 40-43 . |
| APA | Kong, Xianmin , Chen, Tao , Huang, Yinghui . Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips . | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2020 , 131 (1) , 40-43 . |
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摘要 ：
Purpose: The design of pattern that limits the hippocampal cells growth is an important explore for realizing a simplified artificial neuronal network in vitro. Materials and methods: In this study, we examined the pattern in micro-fluidic chip to stipulate the hippocampal cells adhesion, growth and the formation of a functional neuronal network in vitro. Patch clamp recording technique was used to detect the growth situation and biological function of the haippocampal cells on the micro-fluidic chip which could simulate environment in vivo. Results: We showed that the number of neurons cultured was about 5000-6000 cells on the micro-fluidic chip, which was conductive to the hippocampal cells growth. The result of patch clamp recording technique showed the signals of sodium and potassium channels, meanwhile, it also revealed the signals of synaptic connection. Conclusions: These findings involve placing cells in specific locations to create organized structures, and explore the spread function of synaptic on the micro-fluidic chip.
关键词 ：
artificial neuronal network artificial neuronal network Hippocampal cells Hippocampal cells micro-fluidic chip micro-fluidic chip patch clamp recording technique patch clamp recording technique
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| GB/T 7714 | Kong, Xianmin , Tian, Shanshan , Chen, Tao et al. Functional detection of the original generation of hippocampal cells planted on to the micro-fluidic chip with artificial neuronal network using the patch clamp recording technique: a preliminary study [J]. | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2019 , 129 (5) : 430-437 . |
| MLA | Kong, Xianmin et al. "Functional detection of the original generation of hippocampal cells planted on to the micro-fluidic chip with artificial neuronal network using the patch clamp recording technique: a preliminary study" . | INTERNATIONAL JOURNAL OF NEUROSCIENCE 129 . 5 (2019) : 430-437 . |
| APA | Kong, Xianmin , Tian, Shanshan , Chen, Tao , Huang, Yinghui . Functional detection of the original generation of hippocampal cells planted on to the micro-fluidic chip with artificial neuronal network using the patch clamp recording technique: a preliminary study . | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2019 , 129 (5) , 430-437 . |
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摘要 ：
Laser-induced plasma ablation (LIPA) using a 248 nm KrF excimer laser was investigated for microchannel fabrication. Examination of the morphology in relation to ablation performance was emphasized, and a synthetic LIPA mechanism model was proposed based on the results. Backside LIPA with a metal target on the bottom can be attributed to a combination of two phenomena: laser-induced plasma vaporization thermal ablation from the metal target below and enhanced laser-glass direct interaction from the plasma residuum. The laser absorption enhancement of quartz substrate resulting from the metal residuum was validated clearly using absorption spectrum measurements. The influence of laser parameters on the etching quality during LIPA was also analyzed for processing optimization. Finally, fused quartz glass microchannels of outstanding surface quality and dimension uniformity were implemented. The channel depth was 28 mu m, and the bottom surface roughness was better than several hundred nanometers.
关键词 ：
excimer laser excimer laser fused quartz glass fused quartz glass laser ablation laser ablation microstructure microstructure plasma plasma
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| GB/T 7714 | Zhao, Yu , Li, Qian , Wang, Zhengfei et al. Microchannel Fabrication in Fused Quartz by Backside Laser-Induced Plasma Ablation Using 248 nm KrF Excimer Laser [J]. | APPLIED SCIENCES-BASEL , 2019 , 9 (24) . |
| MLA | Zhao, Yu et al. "Microchannel Fabrication in Fused Quartz by Backside Laser-Induced Plasma Ablation Using 248 nm KrF Excimer Laser" . | APPLIED SCIENCES-BASEL 9 . 24 (2019) . |
| APA | Zhao, Yu , Li, Qian , Wang, Zhengfei , Dai, Ziruo , Chen, Tao . Microchannel Fabrication in Fused Quartz by Backside Laser-Induced Plasma Ablation Using 248 nm KrF Excimer Laser . | APPLIED SCIENCES-BASEL , 2019 , 9 (24) . |
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摘要 ：
The present work envisages the development of a novel and low-cost self-mixing interferometry (SMI) technology-based single particle sensing system in a microchannel chip for real time single micro-scale particle sizing. We proposed a novel theoretical framework to describe the impulse SMI signal expression in the time domain induced by a flowing particle. Using Hilbert transform, the interferometric fringe number of the impulse SMI signal was retrieved precisely for particle size discrimination. For the ease of particle sensing, a hydrodynamic focusing microfluidic channel was employed by varying the flow rate ratio between the sample stream and the sheath liquid, and the particle stream of a controllable width was formed very easily. The experimental results presented good agreement with the theoretical values, providing a 300 nm resolution for the particle sizing measurement.
关键词 ：
Hilbert transform Hilbert transform hydrodynamic focusing hydrodynamic focusing microfluidics microfluidics particle sizing particle sizing self-mixing interferometry self-mixing interferometry sensing mechanisms sensing mechanisms
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| GB/T 7714 | Zhao, Yu , Zhang, Menglei , Zhang, Chen et al. Micro Particle Sizing Using Hilbert Transform Time Domain Signal Analysis Method in Self-Mixing Interferometry [J]. | APPLIED SCIENCES-BASEL , 2019 , 9 (24) . |
| MLA | Zhao, Yu et al. "Micro Particle Sizing Using Hilbert Transform Time Domain Signal Analysis Method in Self-Mixing Interferometry" . | APPLIED SCIENCES-BASEL 9 . 24 (2019) . |
| APA | Zhao, Yu , Zhang, Menglei , Zhang, Chen , Yang, Wuxiong , Chen, Tao , Perchoux, Julien et al. Micro Particle Sizing Using Hilbert Transform Time Domain Signal Analysis Method in Self-Mixing Interferometry . | APPLIED SCIENCES-BASEL , 2019 , 9 (24) . |
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摘要 ：
Understanding the mechanism of functional connectivity in neural system is of great benefit to lot of researches and applications. Microfluidics and microelectrode arrays (MEAs) have been frequently utilized for in vitro neural cultures study. However, there are few studies on the functional connectivity of neural cultures grown on a microfluidic chip. It is intriguing to unveil the influences of microfluidic structures on in vitro neuronal networks from the perspective of functional connectivity. Hence, in the present study, a device was established, which comprised a microfluidic chamber for cell growth and a MEA substrate for recording the electrophysiological response of the neuronal networks. The network topology, neural firing rate, neural bursting rate and network burst frequency were adopted as representative characteristics for neuronal networks analysis. Functional connectivity was estimated by means of cross-covariance analysis and graph theory. The results demonstrated that the functional connectivity of the in vitro neuronal networks formed in the microchannel has been apparently reinforced, corresponding to improve neuronal network density and increased small-worldness.
关键词 ：
Neural functional connectivity Neural functional connectivity Neurofluidic device Neurofluidic device Neuronal networks Neuronal networks
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| GB/T 7714 | Shen, Xuefei , Wu, Jiaxi , Wang, Zhengfei et al. Characterization of in vitro neural functional connectivity on a neurofluidic device [J]. | ELECTROPHORESIS , 2019 , 40 (22) : 2996-3004 . |
| MLA | Shen, Xuefei et al. "Characterization of in vitro neural functional connectivity on a neurofluidic device" . | ELECTROPHORESIS 40 . 22 (2019) : 2996-3004 . |
| APA | Shen, Xuefei , Wu, Jiaxi , Wang, Zhengfei , Chen, Tao . Characterization of in vitro neural functional connectivity on a neurofluidic device . | ELECTROPHORESIS , 2019 , 40 (22) , 2996-3004 . |
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摘要 ：
Femtosecond (fs) laser is proved a powerful tool in the field of 3-dimensional internal micromachining inside the transparent dielectrics. There are already many types of femtosecond laser systems widely applied nowadays, among which Ti: sapphire femtosecond laser and femtosecond fiber laser are the two most frequently used typical femtosecond laser systems. However, according to our study, the differences in the laser parameters between these two femtosecond laser systems may induce significant discrepancy in manufacturing internal hollow structures inside the polymethyl methacrylate (PMMA) substrate. The experimental results show that when a 65fs laser beam is focused inside the PMMA substrate and scans a route of a straight line at an average power of 1.5W and 1 kHz repetition rate, a hollow microchannel is successfully fabricated and no melted region is found around the microchannel. However, if the PMMA substrate is constantly irradiated with the 1.5W laser pulses that generated by a 400fs femtosecond fiber laser system at a repetition rate of 100 kHz, a growing hollow cavity is observed and a melted-resolidified region is formed around the cavity. According to the numerical simulation of heat accumulation effect, we explain the 'heat accumulation effect' caused in the femtosecond fiber laser manufacturing and the 'cold processing property' of the Ti: sapphire femtosecond laser processing, respectively. These experimental and numerical results may broaden the understanding of thermal effect during the process of the femtosecond laser micromachining and provides more opportunities in the manufacturing of polymeric integrated microfluidic chip with laser direct writing technology in the future.
关键词 ：
Femtosecond laser manufacturing Femtosecond laser manufacturing heat accumulation effect heat accumulation effect internal manufacturing internal manufacturing PMMA PMMA
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| GB/T 7714 | Zheng, Chong , Feng, Ziqi , Chen, Tao et al. Study of the internal hollow structures fabricated with two typical femtosecond laser systems and their respective applications [C] . 2018 . |
| MLA | Zheng, Chong et al. "Study of the internal hollow structures fabricated with two typical femtosecond laser systems and their respective applications" . (2018) . |
| APA | Zheng, Chong , Feng, Ziqi , Chen, Tao , Hu, Anming , Liu, Shibing , Li, Junwei . Study of the internal hollow structures fabricated with two typical femtosecond laser systems and their respective applications . (2018) . |
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摘要 ：
With the method of mask projection and direct-writing etching on the front surface of silica glass by a 248 nm nanosecond excimer laser, the influence laws of laser pulse energy density, repetition frequency, scanning times on micro-groove cracks are studied, and the mechanisms of laser etching and cracking of silica glass are analyzed. The results show that the mechanism of silica glass etched by a 248 nm nanosecond pulse excimer laser is the joint effects of photoionization and thermal ablation. The laser energy density threshold range for the crack-free etching of JGS1 silica glass is 16-30 J·cm-2 and the etching rate can be up to 500 nm per pulse. With the increase of laser repetition frequency and scanning times, the micro-grooves are easily cracked because of the heat accumulation and plasma micro-explosion shocking. Based on the optimized laser processing parameters, when the width of micro-grooves is less than 100 μm, the processing of crack-free linear-type (the depth is less than or equal to 50 μm) and circular-arc-type (the depth is less than or equal to 28.5 μm) micro-grooves can be achieved. © 2017, Chinese Lasers Press. All right reserved.
关键词 ：
Etching Etching Excimer lasers Excimer lasers Fused silica Fused silica Glass Glass Silica Silica
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| GB/T 7714 | Yang, Guishuan , Chen, Tao , Chen, Hong . Crack-Free Silica Glass Surface Micro-Grooves Etched by 248 nm Excimer Lasers [J]. | Chinese Journal of Lasers , 2017 , 44 (9) . |
| MLA | Yang, Guishuan et al. "Crack-Free Silica Glass Surface Micro-Grooves Etched by 248 nm Excimer Lasers" . | Chinese Journal of Lasers 44 . 9 (2017) . |
| APA | Yang, Guishuan , Chen, Tao , Chen, Hong . Crack-Free Silica Glass Surface Micro-Grooves Etched by 248 nm Excimer Lasers . | Chinese Journal of Lasers , 2017 , 44 (9) . |
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摘要 ：
Micro total analysis system or Lab-on-a-chip, in which microfluidic chips are significant components, has caused wide attention in recent years. CD/DVD manufacturing technology is a highly efficient and low-cost solution to fabricate microfluidic chips. In this paper, microfluidic chips made of polycarbonate (PC) were firstly fabricated by CD/DVD manufacturing technology. The manufacturing process is divided to five main sub-processes which are photomask fabrication, photolithography, electroforming, stamping and thermal bonding. Besides, by repeatedly bonding for three times, the bonding success percentage of the chip could reach about 98 %. The surface roughness of the microstructure in microfluidic chips which has significant influences on thermal bonding success percentage and test results are also detailedly studied. Surface roughness of SU-8 pattern, Ni stamper and cover slips of PC microfluidic chips was measured and analyzed. In the process of electroforming and stamping, the surface roughness is increased. Moreover, influences of cover slips' surface roughness on thermal bonding are analyzed by bonding five groups of cover slips on PC plates with different average surface roughness. The thermal bonding success percentage is obviously reduced with the increase of average surface roughness.
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| GB/T 7714 | Wang, Tong , Wu, Jian , Chen, Tao et al. Surface roughness analysis and thermal bonding of microfluidic chips fabricated by CD/DVD manufacturing technology [J]. | MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS , 2017 , 23 (5) : 1405-1409 . |
| MLA | Wang, Tong et al. "Surface roughness analysis and thermal bonding of microfluidic chips fabricated by CD/DVD manufacturing technology" . | MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS 23 . 5 (2017) : 1405-1409 . |
| APA | Wang, Tong , Wu, Jian , Chen, Tao , Li, Feng , Zuo, Tiechuan , Liu, Shibing . Surface roughness analysis and thermal bonding of microfluidic chips fabricated by CD/DVD manufacturing technology . | MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS , 2017 , 23 (5) , 1405-1409 . |
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